Navigating Challenges in the Retinoid Market: Side Effects and Safety
Despite their proven effectiveness, retinoids in the Retinoid Market face a major challenge related to their side effects and safety profile. The most common side effects of topical retinoids include skin irritation, peeling, dryness, and increased photosensitivity. While these are often manageable with careful use and proper moisturization, they can be a significant barrier to long-term patient compliance. For oral retinoids, such as isotretinoin for severe acne, the risks are more serious and include potential systemic side effects and a severe risk of birth defects.
This teratogenic risk has led to the implementation of strict regulatory programs, such as the iPledge program in the United States, which requires female patients of childbearing age to adhere to a strict set of rules, including regular pregnancy tests and the use of two forms of birth control. The risk of severe side effects and the need for close medical supervision, particularly for prescription-strength retinoids, are a constant factor shaping the regulatory and commercial landscape of the Retinoid Market.